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NCI Drug Dictionary

NCI Drug Dictionary

  

mechlorethamine hydrochloride  Patient Information
The hydrochloride salt of mechlorethamine, a nitrogen mustard and an analogue of sulfur mustard, with antineoplastic and immunosuppressive activities. Mechlorethamine is metabolized to an unstable, highly reactive ethyleniminium intemediate that alkylates DNA, particularly the 7 nitrogen of guanine residues, resulting in DNA base pair mismatching, DNA interstrand crosslinking, the inhibition of DNA repair and synthesis, cell-cycle arrest, and apoptosis. This agent also exhibits lympholytic properties. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:chloramin
chlorethamine HCl
chlorethamine hydrochloride
chlorethazine
chlorethazine hydrochloride
chlormethine
chlormethine hydrochloride
chloromethine HCl
mechlorethamine
mechlorethamine HCl
methylchlorethamine
Mustard
mustargen HCl
mustargen hydrochloride
Mustine
NH-2
N-Lost
US brand name:Mustargen
Foreign brand names:Caryolysine
Cloramin
Erasol
Mustine Hydrochloride
Onco-Cloramin
Abbreviations:HN 2
NM
Acronym:NM
Code name:WR-147650
Chemical structures:bis(2-chloroethyl)methylamine
ethanamine,2-chloro-N-(2-chloroethyl)-N-methyl
methylbis(beta-chloroethyl)amine