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NCI Drug Dictionary


p53 peptide vaccine 
A peptide-based cancer vaccine composed of amino acids 264 to 272 of the wild-type protein encoded by the P53 gene. p53 peptide vaccine may elicit an HLA-A2.1-restricted cytotoxic T lymphocyte immune response against tumor cells that overexpress p53 protein. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:individualized mutant p53 peptide-pulsed cultured autologous dendritic cell vaccine
P53 (264-272) peptide vaccine and tumor-specific mutant p53 peptide vaccine
Abbreviation:p53 VAC