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NCI Drug Dictionary

  

tanespimycin 
A benzoquinone antineoplastic antibiotic derived from the antineoplastic antibiotic geldanamycin. Tanespimycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins; the inhibition of HSP90 promotes the proteasomal degradation of oncogenic signaling proteins that may be overexpressed by tumor cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand name:KOS-953
Abbreviation:17-AAG
Chemical structures:17-allylamino-17-demethoxy-geldanamycin
17-allyl-aminogeldanamycin
17-demethoxy-17-(2-propenylamino)geldanamycin