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NCI Drug Dictionary


recombinant CD40-ligand 
A recombinant therapeutic agent which is chemically identical to or similar to CD40-ligand. CD40-ligand, also known as CD40L/TRAP and CD154, is a type II membrane protein which binds to CD40, a cell surface receptor that belongs to the tumor necrosis factor receptor family; CD40 is expressed on B lymphocytes, monocytes, dendritic cells (DC), hematopoietic progenitors, endothelial cells and epithelial cells. Recombinant CD40-ligand may be used to activate DC ex vivo via CD40 binding; CD40-ligand-activated DC may provide or augment a protective antitumor immunity when administered in dendritic cell cancer vaccines. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:CD154 antigen
gp39 cytokine
T-cell antigen gp39
TNF-related activation protein
TRAP ligand
rhu CD40L