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NCI Drug Dictionary

  

tetradecanoylphorbol acetate 
A phorbol ester with potential antineoplastic effects. Tetradecanoylphorbol acetate (TPA) induces maturation and differentiation of hematopoietic cell lines, including leukemic cells. This agent may induce gene expression and protein kinase C (PKC) activity. In addition to potential antineoplastic effects, TPA may exhibit tumor promoting activity. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:Lonomycin
Phorbol Myristate Acetate
Abbreviations:PMA
TPA
Chemical structure:12-O-tetradecanoylphorbol-13-acetate