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NCI Drug Dictionary

NCI Drug Dictionary

  

thioguanine 
A synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine phosphoribosyltransferase, thioguanine incorporates into DNA and RNA, resulting in inhibition of DNA and RNA syntheses and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine synthesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand names:Tabloid
Tabloid brand thioguanine
Tioguanine
Foreign brand names:Lanvis
Tioguanin
Abbreviations:6-TG
TG
Code names:BW 5071
Wellcome U3B
WR-1141
X 27
Chemical structures:2-Amino 6MP
2-Amino-1,7-dihydro-6H-purine-6-thione
2-Amino-6-mercaptopurine
2-Amino-6-purinethiol
2-Aminopurin-6-thiol
2-Aminopurine-6(1H)-thione
2-Aminopurine-6-thiol
6 Mercaptoguanine
6 Thioguanine
6H-Purine-6-thione, 2-amino-1,7-dihydro- (9CI)
6-Mercapto-2-aminopurine
6-mercaptoguanine
6-thioguanine