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A synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine phosphoribosyltransferase, thioguanine incorporates into DNA and RNA, resulting in inhibition of DNA and RNA syntheses and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine synthesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|US brand names:||Tabloid |
Tabloid brand thioguanine
|Foreign brand names:||Lanvis |
|Code names:||BW 5071 |
|Chemical structures:||2-Amino 6MP |
6H-Purine-6-thione, 2-amino-1,7-dihydro- (9CI)