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NCI Drug Dictionary

  

thioguanine 
A synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine phosphoribosyltransferase, thioguanine incorporates into DNA and RNA, resulting in inhibition of DNA and RNA syntheses and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine synthesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:tioguanin
tioguanine
US brand names:Tabloid
Tabloid
Foreign brand name:Lanvis
Abbreviations:6-TG
TG
Code names:BW 5071
Wellcome U3B
WR-1141
X 27
Chemical structures:2-amino 6MP
2-amino-1,7-dihydro-6H-purine-6-thione
2-amino-6-mercaptopurine
2-amino-6-purinethiol
2-aminopurin-6-thiol
2-aminopurine-6(1H)-thione
2-aminopurine-6-thiol
6 mercaptoguanine
6 thioguanine
6H-purine-6-thione, 2-amino-1,7-dihydro- (9CI)
6-mercapto-2-aminopurine
6-mercaptoguanine
6-thioguanine