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NCI Drug Dictionary

NCI Drug Dictionary

  

semustine 
A methylated derivative of carmustine with antineoplastic activity. As an alkylating agent, semustine forms covalent linkages with nucleophilic centers in DNA, causing depurination, base-pair miscoding, strand scission, and DNA-DNA cross-linking, which may result in cytotoxicity. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:CCNU, methyl-
MCCNU
methyl CCNU
methyl-CCNU
Abbreviation:MeCCNU