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NCI Drug Dictionary


A new generation organic platinum analog with an extended spectrum of antineoplastic activity. Designed to overcome platinum drug resistance, picoplatin alkylates DNA, forming both inter- and intra-strand cross-linkages, resulting in inhibition of DNA replication and transcription, and the induction of apoptosis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Code names:AMD473
NX 473
Chemical structures:Cis-Amminedichloro (2-Methylpyridine) Platinum
Platinum, Amminedichloro(2-methylpyridine)-, (SP-4-3)