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NCI Drug Dictionary


recombinant modified vaccinia Ankara-5T4 vaccine 
A cancer vaccine comprised of a recombinant modified vaccinia Ankara (MVA) viral vector encoding the 5T4 fetal oncoprotein (MVA-h5T4). Vaccination with recombinant modified vaccinia Ankara-5T4 vaccine may stimulate the host immune system to mount a humoral and cytotoxic T lymphocyte (CTL) response against tumor cells expressing 5T4 fetal oncoprotein antigen, resulting in tumor cell lysis. The MVA viral vector, derived from the replication-competent strain Ankara, is a highly attentuated, replication-defective vaccinia strain incapable of virion assembly. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:recombinant MVA-5T4 vaccine
recombinant pox virus encoding 5T4 vaccine
vaccinia-5T4 antigen vaccine
US brand name:TroVax
Foreign brand name:TroVax
Abbreviation:rV-5T4 VAC