NCI Drug Dictionary
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A recombinant protein with megakaryopoiesis stimulating activity. Romiplostim mimics endogenous thrombopoietin (TPO), directly binding to and activating the platelet thrombopoietin receptor (TpoR, Mpl, or CD110 antigen), a cytokine receptor belonging to the hematopoietin receptor superfamily. Activation of TpoR stimulates the proliferation and differentiation of megakaryocytes, resulting in an increase in the production of blood platelets. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|Synonym:||Amgen megakaryopoiesis protein 2|
|US brand name:||Nplate|
|Code name:||AMG 531|
|Chemical structure:||methionyl, 227 amino acid C-terminal immunoglobulin G1 (human Fc fragment) fusion protein with 41 amino acid peptide, dimer|