NCI Drug Dictionary
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A non-essential amino acid. In hepatocytes, L-citrulline is synthesized in the urea cycle by the addition of carbon dioxide and ammonia to ornithine. L-citrulline is converted into L-arginine by the enzymes argininosuccinate synthetase and argininosuccinate lyase in the presence of L-aspartate and ATP. Subsequently, L-arginine is converted to nitric oxide by nitric oxide synthase and L-citrulline is regenerated as a by-product . Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|Chemical structure:||2-amino-5-(carbamoylamino)pentanoic acid|