In English | En español
Questions About Cancer? 1-800-4-CANCER

NCI Drug Dictionary

  

aerosolized liposomal rubitecan 
An aerosolized liposomal preparation of a water-insoluble derivative of camptothecin with potential antineoplastic activity. 9-nitro-20 (S)-camptothecin and its active metabolite 9-aminocamptothecin (9-AC) selectively stabilize topoisomerase I-DNA covalent complexes during S-phase, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. This agent is formulated with dilauroylphosphatidylcholine and nebulized in particle sizes of 1.2-1.6 micrometer mass median aerodynamic diameter. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:aerosolized liposomal 9-nitrocamptothecin
Code name:L9NC