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NCI Drug Dictionary

NCI Drug Dictionary

  

B-Raf/VEGFR-2 inhibitor RAF265 
An orally bioavailable small molecule with potential antineoplastic activity. B-Raf/VEGFR-2 inhibitor RAF265 binds and inhibits Raf kinases, which may result in a reduction of tumor cell growth and proliferation, and tumor cell death. In addition, this agent inhibits vascular endothelial growth factor receptor type 2 (VEGFR-2), thereby disrupting tumor angiogenesis. Raf kinases are critical enzymes in the Ras/Raf/MEK/ERK signaling pathway and are frequently upregulated in neoplasms. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Code names:CHIR-265
RAF265