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NCI Drug Dictionary

  

danusertib 
A small-molecule 3-aminopyrazole derivative with potential antineoplastic activity. Dalotuzumab binds to and inhibits the Aurora kinases, which may result in cell growth arrest and apoptosis in tumor cells in which Aurora kinases are overexpressed. This agent may preferentially bind to and inhibit Aurora B kinase. Aurora kinases, a family of serine-threonine kinases, are important regulators of cellular proliferation and division. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:Aurora kinase inhibitor PHA-739358