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NCI Drug Dictionary

NCI Drug Dictionary

  

gossypol 
An orally-active polyphenolic aldehyde with potential antineoplastic activity. Derived primarily from unrefined cottonseed oil, gossypol induces cell cycle arrest at the G0/G1 phase, thereby inhibiting DNA replication and inducing apoptosis. This agent also inhibits cell-signaling enzymes, resulting in inhibition of cell growth, and may act as a male contraceptive. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:Cottonseed Meal Toxin
Gossypol (Racemic)
Chemical structures:1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)[2,2'-binaphthalene]-8,8'-dicarboxaldehyde
1,1',6,6',7,7'-Hexahydroxy-5,5'-diisopropyl-3-3'-dimethyl[2,2'-binaphthalene]-8,8'-dicarboxaldehyde
2,2'-bis[1,6,7-Trihydroxy-4-methyl-5-isopropyl-8-aldehydonaphthalene
2,2'-bis[8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene]