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NCI Drug Dictionary


MAGE-A1, Her-2/neu, FBP peptides ovarian cancer vaccine 
A cancer vaccine containing multiple synthetic antigen peptides derived from MAGE-A1, Her-2/neu, and folate binding protein (FBP) with potential immunostimulating and antineoplastic properties. MAGE-A1, Her-2/neu, FBP peptides cancer vaccine includes the antigen peptides MAGE-A1:161-169, FBP:191-199, Her-2/neu:369-377, MAGE-A1:96-104, and Her-2/neu:754-762. Upon administration, this cancer vaccine may stimulate the immune system to mount a cytotoxic T-cell (CTL) response against tumor cells expressing these antigen peptides, resulting in tumor cell lysis. MAGE-A1, Her-2/neu, and FBP proteins may be over-expressed in various cancer cell types, such as epithelial ovarian cancer cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)