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NCI Drug Dictionary

  

cenisertib 
An orally bioavailable, synthetic, small-molecule multi-Aurora kinase inhibitor with potential antineoplastic activity. Cenisertib selectively binds to and inhibits multiple Aurora kinases (AKs), which may result in the inhibition of cell division and proliferation, and the induction of apoptosis in tumor cells that overexpress AKs. Overexpressed in certain tumor cell types, AKs, a family of serine-threonine kinases, are important regulators of cell division and proliferation that are involved in controlling chromatid segregation. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:Aurora kinase inhibitor AS703569
Aurora kinase Inhibitor R763
Code names:AS703569
R763