NCI Drug Dictionary
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An orally bioavailable, ATP-competitive, small-molecule inhibitor of BRAF(V600E) kinase with potential antineoplastic activity. Vemurafenib selectively binds to the ATP-binding site of BRAF(V600E) kinase and inhibits its activity, which may result in an inhibition of an over-activated MAPK signaling pathway downstream in BRAF(V600E) kinase-expressing tumor cells and a reduction in tumor cell proliferation. Approximately 90% of
|Synonym:||BRAF(V600E) kinase inhibitor RO5185426|
|US brand name:||Zelboraf|
|Code names:||PLX4032 |