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NCI Drug Dictionary

  

panobinostat 
A cinnamic hydroxamic acid analogue with potential antineoplastic activity. Panobinostat selectively inhibits histone deacetylase (HDAC), inducing hyperacetylation of core histone proteins, which may result in modulation of cell cycle protein expression, cell cycle arrest in the G2/M phase and apoptosis. In addition, this agent appears to modulate the expression of angiogenesis-related genes, such as hypoxia-inducible factor-1alpha (HIF-1a) and vascular endothelial growth factor (VEGF), thus impairing endothelial cell chemotaxis and invasion. HDAC is an enzyme that deacetylates chromatin histone proteins. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:HDAC inhibitor LBH589
histone deacetylase inhibitor LBH589
US brand name:Faridak
Foreign brand name:Faridak
Code name:LBH589