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NCI Drug Dictionary

  

levonorgestrel 
The levorotatory form of norgestrel and synthetic progestogen with progestational and androgenic activity. Levonorgestrel binds to the progesterone receptor in the nucleus of target cells, thereby stimulating the resulting hormone-receptor complex, initiating transcription, and increasing the synthesis of certain proteins. This results in a suppression of luteinizing hormone (LH) activity and an inhibition of ovulation, as well as an alteration in the cervical mucus and endometrium. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:18-Methylnorethisterone
D-(-)-Norgestrel
US brand names:Norplant
Plan B
Chemical structures:(17Alpha)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one
13-Ethyl-17-hydroxy-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one