In English | En español
Questions About Cancer? 1-800-4-CANCER

NCI Drug Dictionary


chk1 inhibitor PF-477736 
A proprietary compound targeting cell cycle checkpoint kinase 1 (chk1) with potential chemopotentiation activity. Chk1 inhibitor PF-477736 inhibits chk1, an ATP-dependent serine-threonine kinase that is a key component in the DNA replication-monitoring S/G2 checkpoint system. By overriding the last checkpoint defense against DNA damaging agent-induced lethal damage, chk1 inhibitor PF-477736 may potentiate the antitumor efficacy of various chemotherapeutic agents against tumor cells with intrinsic checkpoint defects. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Code names:PF-0047736