NCI Drug Dictionary
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A synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity. Efavirenz binds directly to the human immunodeficiency virus type 1 (HIV-1) RT, an RNA-dependent DNA polymerase, blocking its function in viral DNA replication. In combination with other antiretroviral drugs, this agent has been shown to significantly reduce HIV viral load, retarding or preventing damage to the immune system and reducing the risk of developing AIDS. Efavirenz induces activity of the cytochrome P450 system, accelerating its own metabolism. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|US brand name:||Sustiva|
|Foreign brand name:||Stocrin|
|Code names:||DMP-266 |