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NCI Drug Dictionary

NCI Drug Dictionary

  

Raf kinase inhibitor XL281 
An orally active, small molecule with potential antineoplastic activity. XL281 specifically inhibits RAF kinases, located downstream from RAS in the RAS/RAF/MEK/ERK kinase signaling pathway, which may result in reduced proliferation of tumor cells. RAS mutations may result in constitutive activation of the RAS/RAF/MEK/ERK kinase signaling pathway, and have been found to occur frequently in human tumors. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Code name:XL281