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NCI Drug Dictionary

  

bcr-abl p210-b3a2 breakpoint-derived multipeptide vaccine 
A multipeptide vaccine consisting of five peptides derived from the bcr-abl p210-b3a2 breakpoint fusion protein with potential antineoplastic activity. Vaccination with bcr-abl p210-b3a2 breakpoint-derived multipeptide vaccine may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells that express the bcr-abl p210-b3a2 breakpoint fusion protein. In chronic myelogenous leukemia (CML), fusion genes typically result from the fusion of either bcr exon b2 or exon b3 to abl exon a2, resulting in either a b3a2 or a b2a2 gene fusion product. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:CMLVAX100
p210-B3A2-derived peptide vaccine