In English | En español
Questions About Cancer? 1-800-4-CANCER

NCI Drug Dictionary

NCI Drug Dictionary

  

wild-type reovirus 
A serotype 3 Dearing strain (T3D) of reovirus (Respiratory Enteric Orphan virus) with potential oncolytic activity. Reovirus, a dsRNA virus, is able to replicate specifically in cancer cells bearing an activated Ras pathway. In contrast to normal cells, two-thirds of human cancer cells are Ras-activated. Unlike normal cells, Ras-activated tumor cells are deficient in host cellular protein kinase R (PKR) activity and so are unable to mount an antiviral response. In Ras-activated tumor cells, reovirus freely replicates and induces apoptosis; tumor cell lysis frees progeny viral particles to infect surrounding tumor cells. A cycle of infection, replication and cell death may continue until Ras-activated tumor cells are eradicated. PKR (eukaryotic translation initiation factor 2-alpha kinase 2) is activated by viral synthesis of double-stranded RNA and is an important component of innate immunity in vertebrates, protecting against viral infection. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand name:REOLYSIN
Foreign brand name:REOLYSIN