NCI Drug Dictionary
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A salicylic acid derivative with potential antineoplastic activity. Salirasib dislodges all Ras isoforms from their membrane-anchoring sites, thereby preventing activation of RAS signaling cascades that mediated cell proliferation, differentiation, and senescence. RAS signaling is believed to be abnormally activated in one-third of human cancers, including cancers of the pancreas, colon, lung and breast. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|Chemical structure:||s-trans, trans-farnesylthiosalicylic acid|