NCI Drug Dictionary
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glycosylated recombinant human interleukin-7
A glycosylated recombinant protein which is chemically identical to or similar to endogenous human interleukin-7 (IL-7) with hematopoietic and immunopotentiating activities. Naturally produced by bone marrow, thymic stromal, and spleen cells, the cytokine interleukin-7 is a hematopoietic growth factor for progenitor B cells and T cells, stimulating proliferation and differentiation of mature T-cells and natural killer (NK) cells. As with glycosylated endogenous proteins, glycosylation of recombinant proteins may fundamentally affect their biological activity, function, clearance from circulation, and antigenicity; glycosylation of recombinant proteins that are chemically identical to similar to endogenous proteins may render protein structures and biological activities that are more similar to those of glycosylated endogenous proteins. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)