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NCI Drug Dictionary

  

asparaginase Erwinia chrysanthemi  Patient Information
An enzyme isolated from the bacterium Erwinia chrysanthemi (E. carotovora). Asparagine is critical to protein synthesis in leukemic cells, which cannot synthesize this amino acid due to the absence of the enzyme asparagine synthase. Asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia, thereby depleting leukemic cells of asparagine and blocking protein synthesis and tumor cell proliferation, especially in the G1 phase of the cell cycle. This agent also induces apoptosis in tumor cells. The Erwinia-derived product is often used for those patients who have experienced a hypersensitivity reaction to the E. Coli formulation. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:asparaginase-Erwinia
crisantaspasum
cristantaspase
Erwinia L-asparginase
krisantaspaasi
krisantaspas
US brand name:Erwinaze
Foreign brand name:Erwinase