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NCI Drug Dictionary

  

idelalisib  Patient Information
An orally bioavailable, small molecule inhibitor of the delta isoform of the 110 kDa catalytic subunit of class I phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities. Idelalisib inhibits the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), preventing the activation of the PI3K signaling pathway and inhibiting tumor cell proliferation, motility, and survival. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in hematopoietic lineages. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:phosphoinositide-3 kinase delta inhibitor CAL-101
PI3K delta inhibitor CAL-101
US brand name:Zydelig
Code names:CAL-101
GS-1101
Chemical structure:5-fluoro-3-phenyl-2-([S)]-1-[9H-purin-6-ylamino]-propyl)-3H-quinazolin-4-one