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NCI Drug Dictionary

NCI Drug Dictionary

  

tetrodotoxin 
A neurotoxin with potential analgesic activity. Tetrodotoxin binds to the pores of fast voltage-gated fast sodium channels in nerve cell membranes, inhibiting nerve action potentials and blocking nerve transmission. Although found in various species of fish (such as the pufferfish), newts, frogs, flatworms, and crabs, tetrodotoxin, for which there is no known antidote, is actually produced by bacteria such as Vibrio alginolyticus, Pseudoalteromonas tetraodonis, and other vibrio and pseudomonas bacterial species. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand name:Tectin
Foreign brand name:Tectin
Abbreviation:TTX