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NCI Drug Dictionary

NCI Drug Dictionary

  

sotatercept 
A soluble fusion protein composed of the extracellular domain of the activin receptor type IIA (ActRIIA) linked to the Fc portion of human IgG1 with anabolic bone activity. Sotatercept selectively binds to activin, inhibiting its binding to ActRIIA and ActRIIA signaling, resulting in the stimulation of osteoblast activity and the inhibition of osteoclast activity and so normal bone formation and increased bone mineral density and strength. The Fc moiety of this fusion protein binds to the salvage receptor FcRN, preventing its lysosomal degradation and so extending its half-life in the circulatory system. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:decoy activin receptor ACE-011
soluble activin receptor Type IIa IgG-Fc fusion protein ACE-011
Code name:ACE-011