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NCI Drug Dictionary

  

niraparib 
An inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. PARP Inhibitor MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. The PARP family of proteins detect and repair single strand DNA breaks by the base-excision repair (BER) pathway. The specific PARP family member target for PARP inhibitor MK4827 is unknown. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:PARP inhibitor MK4827
Code name:MK4827