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NCI Drug Dictionary

  

Eg5 kinesin-related motor protein inhibitor ARQ 621 
A small-molecule inhibitor of the kinesin-related motor protein Eg5 with potential antineoplastic activity. Eg5 kinesin-related motor protein inhibitor ARQ 621 selectively inhibits the activity of Eg5, which may result in mitotic disruption, apoptosis and cell death. The ATP-dependent Eg5 kinesin-related motor protein (also known as KIF11 or kinesin spindle protein-5) is a plus-end directed kinesin motor protein involved in the regulation of spindle dynamics, including assembly and maintenance, during mitosis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:Eg5 inhibitor ARQ 621
Code name:ARQ 621