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NCI Drug Dictionary

  

botulinum toxin type A 
An injectable formulation of a neurotoxin derived through the fermentation of the Hall strain of Clostridium botulinum type A with neuromuscular transmission inhibitory and analgesic activities. Upon injection into the affected muscle, the heavy chain portion of onabotulinumtoxinA binds to the cell membrane of the motor nerve and is internalized via endocytosis. Upon entry, the light chain portion of the toxin is activated and cleaves the protein SNAP-25, thereby preventing the fusion of acetylcholine (ACh)-containing synaptic vesicles with the cell membrane and, so, the release of ACh into the neuromuscular junction; subsequent binding of ACH to motor end-plate nicotinic acid receptors and ACh-mediated muscle contraction are thus blocked. In addition to ACh, onabotulinumtoxinA may inhibit the release of neuropeptides, such as substance P and glutamate, which may contribute to its analgesic activity. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:abobotulinumtoxinA
botulinum A toxin
botulinum neurotoxin type A
botulinum toxin A
onabotulinumtoxinA
onaclostox
US brand names:BOTOX
Botox cosmetic
Dysport
Abbreviation:BTX-A