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NCI Drug Dictionary

  

rabeprazole sodium 
The sodium salt of the prodrug rabeprazole, a substituted benzimidazole proton pump inhibitor, with potential anti-ulcer activity. After protonation, accumulation, and transformation to the active sulfenamide within the acidic environment of gastric parietal cells, rabeprazole selectively and irreversibly binds to and inhibits the H+, K+ATPase (hydrogen-potassium adenosine triphosphatase) enzyme system located on the parietal cell secretory surface, inhibiting gastric acid secretion. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand name:Aciphex
Foreign brand names:Pariet
Rablet