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NCI Drug Dictionary

  

PI3Ka/mTOR inhibitor PKI-179 
A second generation, small-molecule mimetic of ATP that targets the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. PKI-179 selectively inhibits mTOR and phosphoinositide-3-kinase (PI3K) alpha. By inhibiting the PI3K/mTOR signaling pathway, this agent may inhibit tumor cell proliferation and survival. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Code name:PKI-179