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NCI Drug Dictionary


HSV-1 HF10 
A non-engineered, naturally oncolytic, replication-competent spontaneous herpes simplex virus (HSV) type I mutant variant. Upon intratumoral injection, HSV1 HF10 transfects, replicates in, and lyses rapidly dividing cells such as tumor cells. In addition, this agent may increase host immune responses that may kill non-infected tumor cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:herpes simplex virus type 1 HF10
Code name:HF10