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NCI Drug Dictionary

NCI Drug Dictionary

  

3'-aminomethyl nicotine-P. aeruginosa r-exoprotein A conjugate vaccine 
A hapten-carrier immunoconjugate composed of the hapten trans-3′-aminomethyl nicotine conjugated to a recombinant P. aeruginosa exoprotein A, rendered nontoxic through amino acid depletion, with potential immunostimulating activity. Upon vaccination with 3'-aminomethyl nicotine-P. aeruginosa r-exoprotein A conjugate vaccine, the immune system may produce anti-nicotine antibodies. Antibody-bound nicotine cannot pass the blood brain barrier (BBB) to activate brain nicotine receptors. Nicotine, a small organic molecule that is not immunogenic, must be haptenized and conjugated to a carrier protein, such as nontoxic recombinant P. aeruginosa exoprotein A, to induce an antibody response. Aluminium hydroxide may be used as an adjuvant for this vaccine. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:nicotine conjugate vaccine
US brand name:NicVax