NCI Drug Dictionary
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Eg5 kinesin-related motor protein inhibitor 4SC-205
A small-molecule inhibitor of the human kinesin-related motor protein Eg5 with potential antineoplastic activity. Eg5 kinesin-related motor protein inhibitor 4SC-205 selectively inhibits the activity of Eg5, which may result in mitotic disruption, apoptosis and cell death. The ATP-dependent Eg5 kinesin-related motor protein (also known as KIF11 or kinesin spindle protein-5) is a plus-end directed kinesin motor protein essential for the regulation of spindle dynamics, including assembly and maintenance, during mitosis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|Synonym:||Eg5 kinesin inhibitor 4SC-205|