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NCI Drug Dictionary


A monoclonal antibody against RON (recepteur d'origine nantais; macrophage stimulating 1 receptor), with potential antineoplastic activity. Narnatumab binds to RON, thereby preventing binding of its ligand hepatocyte growth factor-like protein (HGFL or macrophage-stimulating protein (MSP)). This may prevent RON receptor-mediated signaling and may prevent cellular proliferation in tumor cells overexpressing RON. RON, a receptor tyrosine kinase, is overexpressed in a variety of epithelial cancer cell types and plays an important role in cellular proliferation, migration and invasion. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:anti-RON monoclonal antibody IMC-RON8
Code names:IMC RON8