NCI Drug Dictionary
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alpha-fetoprotein peptide-pulsed autologous dendritic cell vaccine
A cell-based cancer vaccine comprising autologous dendritic cells pulsed with four alpha-fetoprotein (AFP) peptides, with potential immunostimulatory and antineoplastic activities. Upon administration, AFP peptide-pulsed autologous dendritic cell vaccine may stimulate anti-tumoral cytotoxic T lymphocyte (CTL) and antibody responses against AFP-expressing cancer cells, resulting in tumor cell lysis. AFP is overexpressed in a variety of cancer cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|Abbreviation:||AFP peptide-pulsed autologous dendritic cell vaccine|