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NCI Drug Dictionary


eIF4E antisense oligonucleotide ISIS 183750 
A second-generation antisense oligonucleotide targeting the eukaryotic translation initiation factor 4E (eIF4E) with potential antitumor activity. Antisense oligonucleotide ISIS EIF4ERx suppresses the expression of eIF4E in fast dividing tumor cells. Blocking the expression of eIF4E results in inhibition of the synthesis of tumor angiogenic factors, thereby leading to the inhibition of cellular proliferation and apoptosis in tumor cells. eIF4E is overexpressed in a variety of cancers, is involved in the mRNA-ribosome binding step of eukaryotic protein synthesis and is the rate-limiting component of the eukaryotic translation apparatus. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:eIF4E inhibitor ISIS 183750
eIF4E modulator ISIS 183750
Code names:ISIS 183750