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NCI Drug Dictionary


MAGE-A3 reactive T cell receptor-transduced autologous T cells 
Human autologous T-lymphocytes transduced with a retroviral vector encoding a T cell receptor (TCR) specific for the human melanoma antigen A3 (MAGE-A3), with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the MAGE-A3 reactive TCR-transduced autologous T cells bind to tumor cells expressing MAGE-A3, which may halt the growth of MAGE-A3-expressing cancer cells; the TCR is specific for MAGE-A3:168-176. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:MAGE-A3 T cell receptor-transduced autologous T cells
MAGE-A3 TCR-transduced autologous T cells