NCI Drug Dictionary
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allogeneic acute myeloid leukemia antigen-expressing dendritic cell vaccine
A cancer vaccine consisting of allogeneic, immortalized dendritic precursor cells derived from a patient with acute myelogenous leukemia (AML), with potential immunostimulatory and antineoplastic activities. Upon ex vivo stimulation and expansion of the precursor cells into mature, fully functional dendritic cells (DCs) and subsequent administration, the allogeneic AML antigen-expressing DC vaccine may elicit a potent cytotoxic T-cell (CTL) and antibody response against AML antigen-expressing cells, resulting in tumor cell death. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|Code names:||DCOne |