NCI Drug Dictionary
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allogeneic GM-CSF-secreting tumor vaccine PANC 6.03 pcDNA-1/GM-Neo
An allogeneic cancer vaccine composed of lethally irradiated, whole pancreatic cancer cells transfected with a plasmid carrying the gene for cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF), with potential immunostimulating and antineoplastic activities. Allogeneic GM-CSF–secreting tumor vaccine PANC 6.03 pcDNA-1/GM-Neo secretes GM-CSF thereby activating dendritic cells, promoting antigen presentation to B- and T-cells, and promoting a cytotoxic T-lymphocyte (CTL) response. This may eventually kill tumor cells. The pancreatic tumor cells are derived from the PANC 6.03 tumor cell line. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|Synonym:||PANC 6.03 pcDNA-1/GM-Neo|