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NCI Drug Dictionary


long-acting granulocyte colony-stimulating factor receptor SPI-2012 
A long-acting, recombinant analog of the endogenous human granulocyte colony-stimulating factor (G-CSF) with hematopoietic activity. Similar to G-CSF, long-acting G-CSF analog SPI-2012 binds to and activates specific cell surface receptors and stimulates neutrophil progenitor proliferation and differentiation, as well as selected neutrophil functions. Therefore, this agent may decrease the duration and incidence of chemotherapy-induced neutropenia. The long-acting G-CSF analog SPI-2012 extends the half-life of G-CSF, allowing for administration once every 3 weeks. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Code names:HM10460A