NCI Drug Dictionary
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A synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake. This results in a depletion of glycogen stores and leads to reduced formation of ATP required for survival and reproduction of the helminth. This eventually causes the helminths death. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|US brand name:||Vermox|
|Code name:||R 17635|
|Chemical structures:||(5-benzoyl-1H-benzimidazol-2-yl)-carbamic acid methyl ester |
Methyl 5-benzoyl benzimidazole-2-carbamate