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NCI Drug Dictionary


UV1 telomerase peptide vaccine 
A synthetic, peptide cancer vaccine directed against the human telomerase reverse transcriptase catalytic subunit (hTERT) with potential immunomodulating activity. Vaccination with the UV1 telomerase peptide may stimulate cytotoxic T-cells to recognize and kill telomerase-expressing cells. Telomerase, a reverse transcriptase normally repressed in healthy cells, is overexpressed in most cancer cells and plays a key role in cellular proliferation. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:UV1/hTERT peptide vaccine