NCI Drug Dictionary
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The orally available disodium salt form of eprodisate, a negatively charged sulfonated inhibitor of fibrillogenesis, that can be used in the treatment of amyloid A (AA) amyloidosis. Upon administration, eprodisate competitively binds to the glycosaminoglycan binding sites on serum amyloid A (SAA), which inhibits the formation of the glycosaminoglycan-amyloid fibril aggregate. This prevents the formation of amyloid deposits in certain organs, especially the kidneys, in AA amyloidosis. Check for active clinical trials or closed clinical trials using this agent.
|US brand name:||Kiacta|
|Code name:||NC 503|
|Chemical structure:||1,3-propanedisulfonic acid, disodium salt|