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NCI Drug Dictionary

NCI Drug Dictionary

  

FGFR inhibitor debio 1347 
An orally bioavailable inhibitor of the fibroblast growth factor receptor subtypes 1 (FGFR-1), 2 (FGFR-2) and 3 (FGFR-3), with potential antineoplastic activity. FGFR inhibitor debio 1347 binds to and inhibits FGFR-1, -2, and -3, which result in the inhibition of FGFR-mediated signal transduction pathways. This leads to the inhibition of both tumor cell proliferation and angiogenesis, and causes cell death in FGFR-overexpressing tumor cells. FGFR, a family of receptor tyrosine kinases upregulated in many tumor cell types, is essential for tumor cellular proliferation, differentiation and survival. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:CH5183284
debiopharm 1347
FF284
Code names:debio 1347
debio 1347-101